If you take the marble staircases
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Figure 3As discussed already, misfolded proteins result when a protein follows the wrong folding pathway or energy minimizing funnel, and misfolding can happen spontaneously. Most of the time, only the native conformation is produced in the cell. But as millions and millions of copies of each protein are made during our lifetimes, sometimes a random event occurs and one of these molecules follows the wrong path, changing into a toxic configuration.
